Programmed Death Ligand 1 (PD-L1) Expression in Lung Adenocarcinoma Patients

Authors

  • Rahmat Hidayat Universitas sumatera utara
  • Noni Novisari Soeroso Universitas Sumatera Utara
  • Elisna Syahruddin Universitas Indonesia
  • Dian Cahyadi Universitas Indonesia
  • Setiaputra Universitas Indonesia

DOI:

https://doi.org/10.36497/respirsci.v1i3.16

Keywords:

Programmed Death Ligand 1 (PD-L1), lung adenocarcinoma, Tumor Proportion Score (TPS), Immunohistochemistry

Abstract

Background: Programmed Death Ligand 1 (PD-L1) is a protein found in tumor cells that could inactivate T-cells. This research was done to identify the characteristics of lung adenocarcinoma patients to PD-L1 expression in Medan. 

Method: Descriptive research with a cross-sectional design was used and the study was done for 12 months (January – December 2018). Sample’s collection was done at RSUP (Central Public Hospital) H. Adam Malik and the samples diagnosed with lung adenocarcinoma based on histopathological subtyping were sent to the laboratory of Dharmais Jakarta Hospital where the Ventana 22C3 Immunohistochemistry Staining was done.

Results: Staining was done in 52 samples at Dharmais Jakarta Hospital and only 35 samples were deemed acceptable. In this study, participants’ ages ranged from 40 to 60 years, where the majority were male patients, 31 (88.6%) and 33 patients (82.5%) were at an advanced stage (III and IV).

Conclusion: The study found that the PD-L1 expression was mostly observed in male at the age range of 40 – 60 years and stage IV lung adenocarcinoma patients with Tumour Proportion Score (TPS) of 1 – 49%.

Author Biographies

Noni Novisari Soeroso, Universitas Sumatera Utara

Department of Pulmonology and Respiratory Medicine, Faculty of Medicine

Elisna Syahruddin, Universitas Indonesia

Department of Pulmonology and Respiratory Medicine, Faculty of Medicine

Dian Cahyadi, Universitas Indonesia

Department of Anatomical Pathology, Faculty of Medicine

Setiaputra, Universitas Indonesia

Department of Anatomical Pathology, Faculty of Medicine

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Published

2021-06-23

How to Cite

Hidayat, R., Soeroso, N. N., Syahruddin, E., Cahyadi, D., & Setiaputra. (2021). Programmed Death Ligand 1 (PD-L1) Expression in Lung Adenocarcinoma Patients. Respiratory Science, 1(3), 162-165. https://doi.org/10.36497/respirsci.v1i3.16