Prognostic Significance of Absolute Neutrophil and Eosinophil Counts in AECOPD in Kolonel Abundjani Bangko General Hospital:  A Retrospective Study

Hafifah Hafifah; Derallah A  Lindra; Diniwati  Mukhtar; Helwiyah  Umniyati; Endang  Purwaningsih; Ahmad Rusdan H  Utomo; Faisal  Yunus

doi:10.36497/respirsci.v6i3.230

Authors

Hafifah Hafifah Kolonel Abundjani General Hospital, Jambi
Derallah A Lindra Kolonel Abundjani General Hospital, Jambi - Biomedical Science Doctoral Program, University of Yarsi, Jakarta
Diniwati Mukhtar Biomedical Science Doctoral Program, University of Yarsi, Jakarta
Helwiyah Umniyati Biomedical Science Doctoral Program, University of Yarsi, Jakarta
Endang Purwaningsih Biomedical Science Doctoral Program, University of Yarsi, Jakarta
Ahmad Rusdan H Utomo Biomedical Science Doctoral Program, University of Yarsi, Jakarta
Faisal Yunus Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta

DOI:

https://doi.org/10.36497/respirsci.v6i3.230

Keywords:

absolute neutrophil and eosinophil counts, AECOPD

Abstract

Background: Chronic obstructive pulmonary disease (COPD) is a chronic and progressive respiratory condition characterized by persistent airflow obstruction. The disease trajectory is often punctuated by episodes of acute exacerbation, which significantly aggravate clinical status and increase healthcare burden. The biological plausibility and differential inflammatory pathways of these cell populations suggest evaluating the relationship between neutrophil and eosinophil profiles and the one-year exacerbation frequency in patients with acute COPD.

Method: This study was conducted using a retrospective observational analytic design and included all patients with a confirmed diagnosis of acute exacerbation of chronic obstructive pulmonary disease (AECOPD) who fulfilled the established inclusion criteria at Kolonel Abundjani Bangko General Hospital during April to December 2024. Clinical and laboratory data were retrieved from hospital medical records and subsequently analyzed using appropriate statistical methods.

Results: Thirty-eight patients fulfilled the predefined inclusion criteria and were subsequently enrolled in the analysis. The respondents were predominantly male (94.7%), older than 55 years (89.5%), with a documented smoking history (92.1%), with relatively short admissions (1–4 days) in 68.4%, and survival at discharge was observed in 94.7% of patients. Inferential statistical testing demonstrated no significant relationship between neutrophil or eosinophil counts and clinical prognosis in patients experiencing AECOPD (P>0.05).

Conclusion: Neutrophil nor eosinophil counts demonstrated a statistically significant association with prognostic indicators among patients admitted with acute COPD. However, elevated neutrophil levels (>8) were consistently more prevalent across prognostic strata compared with increased eosinophil counts. This distribution pattern suggests a relative predominance of neutrophil-mediated inflammatory activity during acute exacerbations.