Vitamin C Supplementation Improves Pulmonary Tuberculosis Patients' Sputum Conversion During Intensive Phase Category I Treatment in Medan

Authors

  • Elok Ariyani Safitri Universitas Sumatera Utara
  • Parluhutan Siagian Universitas Sumatera Utara
  • Bintang Yinke Magdalena Sinaga Universitas Sumatera Utara
  • Putri Chairani Eyanoer Universitas Sumatera Utara

DOI:

https://doi.org/10.36497/respirsci.v2i2.30

Keywords:

Mycobacterium tuberculosis, Vitamin C, AFB sputum conversion

Abstract

Background: Many factors influence the success of the acceleration of Acid-Fast Bacilli (AFB) sputum conversion in the treatment of the intensive phase of pulmonary tuberculosis (TB). One of these factors is the nutritional status or nutrition of pulmonary TB patients. Through a fenton reaction, Vitamin C is known to be able to sterilize Mycobacterium tuberculosis. This study aims to determine the effect of giving vitamin C on the conversion of AFB sputum in the intensive phase of pulmonary TB treatment.

Method: This study was an inferential, quasi-experimental evaluation of the acceleration of AFB sputum conversion following vitamin C supplementation in patients with category I pulmonary TB. The study group was separated into two groups: 40 TB patients getting Anti Tuberculosis Treatment (ATT) with vitamin C, and 40 TB patients receiving ATT with placebo. Every two weeks, AFB sputum was examined, and vitamin C levels were measured before and after two months of therapy.

Results: Conversion of AFB occurred sooner in the vitamin C group of pulmonary TB patients, with as many as 29 patients (72.5%) experiencing conversion of AFB sputum at the end of the second week of therapy, whereas there was no conversion in the placebo group. At the end of the fourth week, all patients (100%) given vitamin C showed AFB sputum conversion, whereas only eight patients (20%) in the placebo group had conversion at the end of the fourth week of treatment. Vitamin C levels increased significantly in the group of pulmonary tuberculosis patients who received vitamin C supplementation.

Conclusion: Vitamin C supplementation in the treatment of pulmonary TB can accelerate the conversion of AFB sputum, which is statistically significant.

Author Biographies

Elok Ariyani Safitri, Universitas Sumatera Utara

Department of Pulmonology and Respiratory Medicine, Faculty of Medicine

Parluhutan Siagian, Universitas Sumatera Utara

Department of Pulmonology and Respiratory Medicine, Faculty of Medicine

 

Bintang Yinke Magdalena Sinaga, Universitas Sumatera Utara

Department of Pulmonology and Respiratory Medicine, Faculty of Medicine

Putri Chairani Eyanoer, Universitas Sumatera Utara

Training research Advocacy and teaching (Epi-Treat) Unit

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Published

2022-02-28

How to Cite

Safitri, E. A. ., Siagian, P. ., Sinaga, B. Y. M. ., & Eyanoer, P. C. . (2022). Vitamin C Supplementation Improves Pulmonary Tuberculosis Patients’ Sputum Conversion During Intensive Phase Category I Treatment in Medan. Respiratory Science, 2(2), 72-77. https://doi.org/10.36497/respirsci.v2i2.30